Effective acne management depends not only on disease control but also on treatment tolerability. Retinoids, benzoyl peroxide (BPO), acids, keratolytics, and isotretinoin target comedogenesis, microbial load, and inflammation but may cause dryness, peeling, tightness, burning, stinging, erythema, scaling, and increased transepidermal water loss (TEWL).^[1] These barrier-stress signals can reduce adherence and compromise treatment outcomes. Hydration depends on corneocyte integrity, natural moisturizing factors, lipid lamellae, and controlled water loss; therefore, oily skin may remain dehydrated and sensitive. A practical approach is to start low, go slow, simplify, and review, using gentle cleansing, moisturizer, and photoprotection while avoiding unnecessary active stacking. Humectants such as hyaluronic acid (HA) provide water-binding, lightweight hydration and complement ceramides and film-forming ingredients.^[2] Supportive skincare should be introduced early to preserve comfort and adherence without replacing active acne therapy. The clinical goal is treat acne effectively while protecting the skin barrier so patients can remain on therapy.